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KMID : 0378019750180081061
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New Medical Journal
1975 Volume.18 No. 8 p.1061 ~ p.1065
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Clinical Effectiveness of Minocycline in the Treatment of Neurosurgical Patients
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都鍾雄/Doh, J.O.
鄭相燮/金相喆/李揆彰/李憲梓/Chung, S.S./Kim, S.C./Lee, K.C./Lee, H.J.
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Abstract
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Minocycline, 7-dimethylamino-6- deoxy-6-demethyltetracycline is a new semisynthetic tetracycline which has a broad antibacterial spectrum. It is effective in vitro aganist many Gram-positive- and Gram-negative bacteria including tetracycline-resistant staphylococci and pseudomonas species. Several reports in the literature attest to its in vitro effectiveness, suggesting that it is the most effective tetracycline now available for clinical use. Animal studies have been reported on its effectiveness in vivo, but there are few reports in the clinical literature of the use of Minocycline in the, treatment of human diseases except urinary and upper respiratory tract infections. ,
In this report, the. in vitro activity of Minocycline against a number of pathogenic bacterial
I strains, compared with various antibiotics, is described as well as the clinical- effectiveness- of this drug_ in the. treatment of various infectious diseases in the neurosurgical field.
1) In various neurosurgical infectious diseases, 69 pathogenic bacterial strains were isolated from 52 patients. Staphyloccus aureus was the most common organism(42%) and pseudomonas, E. coli, and proteus strain followed in order.
2) In antibiotic sensitivity of 69 strains tested, Minocycline showed the most broad antibacterial spectrum and highly sensitive to various organisms especially staphylococcus aureus and pseudomonas strain compare with gentamycin, ampicillin and knamycin.
3) Forty out of 52 patients responded well clinically to Minocycline theraphy within 15 days of treatment and no serious side effects were noted except ocassonal.
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